What are the possible triggers for malignant hyperthermia?

Triggering Agents According to the Malignant Hyperthermia Association of the United States (MHAUS), the following agents approved for use in the U.S. are known triggers of MH: inhaled general anesthetics, halothane, desflurane, enflurane, ether, isoflurane, sevoflurane, and succinylcholine.

What anesthetic agents trigger MH?

Anesthetic agents, which may trigger MH in susceptible individuals, are the depolarizing muscle relaxant, succinyl choline and all the volatile anesthetic gasses. Nitrous oxide, intravenous induction agents, benzodiazepines, opioids, and the non-depolarizing relaxants do not trigger MH.

Is succinylcholine a trigger for MH?

The muscle relaxant succinylcholine is also a trigger for MH. No other anesthetic drugs appear to be triggers, including propofol and ketamine.

Which anesthetic agent is a trigger in susceptible individuals for malignant hyperthermia?

Malignant hyperthermia (MH) is an autosomal dominant disorder that may present with a hypermetabolic crisis when susceptible individuals are exposed to volatile anesthetics or succinylcholine.

How does succinylcholine trigger malignant hyperthermia?

Malignant hyperthermia (MH) is a clinical syndrome that occurs during anesthesia with a potent volatile agent (e.g., halothane) and the depolarizing muscle relaxant succinylcholine, which produces rapidly increasing temperature and extreme acidosis.

How do you get hyperthermia?

Hyperthermia often occurs during physical exertion or exercise in a warm or humid environment. During exercise, blood pressure rises to deliver more oxygen to working tissues, increasing body temperature and the amount of work the body must do to maintain a stable temperature.

Is rocuronium a trigger for MH?

Here investigators report two cases in which the nondepolarizing agent rocuronium is thought to have triggered malignant hyperthermia in patients with no known history of the disorder.

Does Propofol trigger malignant hyperthermia?

Propofol may be a useful anesthetic in the management of malignant hyperthermia patients. It appears not to trigger malignant hyperthermia while providing stress-free conditions.

Why does succinylcholine trigger malignant hyperthermia?

Do local anesthetics trigger malignant hyperthermia?

Malignant hyperthermia is a genetically transmitted complication of general or local anesthesia, with a high mortality rate.

Does propofol cause malignant hyperthermia?

Abstract. Propofol may be a useful anesthetic in the management of malignant hyperthermia patients. It appears not to trigger malignant hyperthermia while providing stress-free conditions.

What are the 3 main conditions hyperthermia causes?

Heat fatigue, heat syncope (sudden dizziness after prolonged exposure to the heat), heat cramps, heat exhaustion and heat stroke are commonly known forms of hyperthermia. Risk for these conditions can increase with the combination of outside temperature, general health and individual lifestyle.