What are the 2 meglitinides?

What are the 2 meglitinides?

Meglitinides are oral medications used to treat type 2 diabetes. They work by triggering production of insulin. Medications in this class include Prandin (repaglinide) and Starlix (nateglinide).

What are examples of meglitinides?

Meglitinides stimulate a shorter term burst of insulin to cover mealtimes. Common brands include: Repaglinide (marketed as Prandin) Nateglinide (marketed as Starlix)…What?

  • Chlorpropamide (marketed as Diabinese)
  • Glipizide (marketed as Glucotrol)
  • Glyburide (marketed as DiaBeta)
  • Glimepiride (marketed as Amaryl)

What is another name for meglitinides?

Generic name: nateglinide For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

What is the mechanism of action of meglitinides?

Mechanism of action Meglitinides (glinides) are based on the sulfonylurea moiety of glibenclamide (called meglitinide). They bind to the SUR1 receptor on the β-cell, although with lower affinity than sulfonylureas, and stimulate insulin release in the same way.

Which drugs are meglitinides?

One drug class commonly used in the treatment of Type 2 diabetes to control blood glucose levels is called meglitinides. Meglitinides require a prescription and include two drugs—repaglinide and nateglinide. Both drugs are approved by the U.S. Food and Drug Administration (FDA) and are available in tablet form.

What class is meglitinides?

Repaglinide is a drug used in the treatment of diabetes mellitus type 2. It belongs to a class of antihyperglycemic agents known as meglitinides, along with nateglinide. Meglitinides work to reduce blood glucose levels by stimulating endogenous insulin production.

Can sulfonylureas be used with meglitinides?

Although meglitinides can be used alone or together with other agents (e.g., metformin; Bailey, 2013), they should not be used with sulfonylureas because of their similar action (Kalra & Gupta, 2015; NIDDKD, 2015).

How does the meglitinides differ from the sulfonylureas?

Meglitinides (eg, repaglinide, nateglinide) are much shorter-acting insulin secretagogues than the sulfonylureas are, with preprandial dosing potentially achieving more physiologic insulin release and less risk for hypoglycemia.