Why do I have low gamma globulin?

Hypogammaglobulinemia may result from a variety of primary genetic immune system defects, such as common variable immunodeficiency, or it may be caused by secondary effects such as medication, blood cancer, or poor nutrition, or loss of gamma globulins in urine, as in nonselective glomerular proteinuria.

What disease is related to low immunoglobulin levels?

Common autoimmune conditions found with IgA deficiency include rheumatoid arthritis, lupus, celiac disease or inflammatory bowel disease.

What causes globulin deficiency?

Mutations in the SERPINA6 gene cause corticosteroid-binding globulin deficiency. The SERPINA6 gene provides instructions for making a protein called corticosteroid-binding globulin (CBG), which is primarily produced in the liver. The CBG protein attaches (binds) to a hormone called cortisol .

What autoimmune diseases cause low IgG?

Various autoimmune diseases are associated with IgA deficiency, including rheumatoid arthritis, systemic lupus erythematosus, Graves disease, type 1 diabetes, celiac disease, myasthenia gravis, pernicious anemia, and immune thrombocytopenic purpura.

Is hypogammaglobulinemia an autoimmune disease?

Many autoimmune diseases have been described in the course of hypogammaglobulinemia, such as cytopenias, inflammatory bowel disease, seronegative arthritis, Sjögren’s syndrome, uveitis, vasculitis, and vitiligo (22,23).

Does low IgG cause fatigue?

Fatigue Is Common in Immunoglobulin G Subclass Deficiency and Correlates With Inflammatory Response and Need for Immunoglobulin Replacement Therapy. Purpose: Individuals with immunoglobulin G deficiency (IgGsd) often complain of fatigue. The correlation between systemic inflammation and fatigue is unknown.

What are the symptoms of low IgG?

What are the symptoms of an IgG deficiency?

• Sinus infections and other respiratory infections.
• Gastrointestinal infections.
• Ear infections.
• Pneumonia.
• Bronchitis.
• Infections that result in a sore throat.
• Rarely, severe and life-threatening infections.

What happens if globulin ratio is low?

Low A/G ratio: This might be the sign an autoimmune disorder, where your body’s immune system attacks healthy cells. It can also point to kidney disease or cirrhosis, which is inflammation and scarring of the liver. In some cases, a low A/G ratio can be a sign of a tumor in your bone marrow.

Is hypogammaglobulinemia a disease or disorder?

Hypogammaglobulinemia is a disorder caused by low serum immunoglobulin or antibody levels. Immunoglobulins are the main components of the humoral immune response and able to recognize antigens to trigger a biological response and eradicate the infectious source.

Does multiple myeloma have hypogammaglobulinemia?

Hypogammaglobulinemia may be congenital or acquired. Among the acquired causes are multiple myeloma and primary amyloidosis. Panhypogammaglobulinemia can occur in approximately 10% of cases of multiple myeloma.