What Catie found results from the schizophrenia trial?
What Catie found results from the schizophrenia trial?
The CATIE finding of no difference in tardive dyskinesia risk across treatment groups is consistent with the findings of a meta-analysis of 31 randomized controlled trials, which found no greater risk of extrapyramidal symptoms between low-potency first-generation antipsychotics and second-generation antipsychotics …
What did the Catie trial show?
The CATIE study showed that each drug might be most useful in particular situations. For patients whose symptoms did not improve with first-line treatment, clozapine was most effective. Olanzapine was effective in all phases of the study, but it and clozapine had the greatest side effect liabilities.
Does olanzapine cause weight gain?
Olanzapine elicits the most weight gain of the SGAs. The Comparison of Atypicals for First Episode (CAFE) trial demonstrated that 80% of patients treated with olanzapine gained more than 7% of their initial body weight at week 52 (McEvoy et al., 2007).
What is perphenazine used for?
Perphenazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Perphenazine is also used to control severe nausea and vomiting in adults.
What is the most common negative symptom of schizophrenia?
Negative symptoms experienced by people living with schizophrenia include: losing interest and motivation in life and activities, including relationships and sex. lack of concentration, not wanting to leave the house, and changes in sleeping patterns.
How effective are antipsychotics for schizophrenia?
After 6 weeks, the proportion of patients who showed a marked to moderate degree of improvement was 75% for those who received antipsychotic treatment and 23% for those who received placebo. There were no significant differences in efficacy between the three antipsychotics assessed.
What is cariprazine used for?
Cariprazine is a medication that works in the brain to treat schizophrenia. It is also known as a second-generation antipsychotic (SGA) or atypical antipsychotic. Cariprazine rebalances dopamine and serotonin to improve thinking, mood, and behavior.
Does olanzapine cause memory loss?
The 2 main hypotheses of this study were confirmed: olanzapine improved multiple cognitive domains, including those known to be important in functional outcome such as verbal learning and memory and attention, and olanzapine did not impair measures sensitive to anticholinergic drugs, including verbal and spatial memory …
Does olanzapine cause hair loss?
Drug-induced alopecia is a side effect characterized by generalized hair loss. It is reversible when the drug is discontinued. Among psychotropic agents, this side-effect is most often reported with the use of valproic acid and lithium.
What is the oldest antipsychotic drug?
Chlorpromazine. Chlorpromazine is a phenothiazine antipsychotic that is a dopamine D2 receptor antagonist. It was the first conventional antipsychotic developed and is still in wide use for treatment of schizophrenia.