What is interferon gamma used for?
What is interferon gamma used for?
Interferon gamma-1b injection is used to lower the frequency and severity of serious infections caused by chronic granulomatous disease (CGD). It is also used to slow down the progression of severe, malignant osteopetrosis (SMO).
How is actimmune administered?
ACTIMMUNE® (Interferon gamma-1b) should be administered subcutaneously 3 times weekly. It can be injected by the patient or caregiver after appropriate training by a healthcare professional.
Is interferon gamma a drug?
Interferon gamma-1b is in a class of medications called immunomodulators. It is not known exactly how interferon gamma-1b works to treat chronic granulomatous disease and osteopetrosis.
Is interferon gamma FDA approved?
ACTIMMUNE® (Interferon gamma-1b) is approved by the FDA to delay time to disease progression in patients with severe malignant osteopetrosis (SMO). ACTIMMUNE® is believed to work by changing how some cells in your body work. This includes the cells that help form your bones.
What are gamma injections for?
Gamma globulin injections are usually given in an attempt to temporarily boost a patient’s immunity against disease. Injections are most commonly used on patients having been exposed to hepatitis A or measles, or to make a kidney donor and a recipient compatible regardless of blood type or tissue match.
Who makes actimmune?
Visit www.ACTIMMUNE.com to download a copy of the ACTIMMUNE Full Prescribing Information. Horizon Pharma plc is a biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.
What is chronic granulomatous inflammation?
Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are highly susceptible to frequent and sometimes life-threatening bacterial and fungal infections.
What inhibits interferon gamma?
These results show that mIFN-gamma R-IgG is an effective and specific inhibitor of mIFN-gamma both in vitro and in vivo. Thus, in general, IFN-gamma receptor immunoadhesins may be useful for investigating the biological functions of IFN-gamma as well as for preventing deleterious effects of IFN-gamma in human disease.
When was Actimmune approved by the FDA?
ACTIMMUNE® (Interferon gamma-1b) was approved by the FDA in 1990 after a study was conducted with 128 people who had chronic granulomatous disease (CGD). The most common ACTIMMUNE® side effects found during the study were flu-like symptoms. These included fever, headache, chills, muscle pain, or tiredness.
Why is gamma globulin given?
What does gamma globulin protect you from?
From the studies reviewed it is apparent that gamma globulin is of value in preventing hepatitis both when administered as mass prophylaxis in an epidemic, and when given to persons in close contact with a person who has the disease.
Which cells respond to IFN-gamma?
IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance.
How do interferons activate white blood cells?
Interferon is secreted by cells in response to stimulation by a virus or other foreign substance, but it does not directly inhibit the virus’s multiplication. Rather, it stimulates the infected cells and those nearby to produce proteins that prevent the virus from replicating within them.
Why is interferon gamma used for CGD?
IFN-gamma stimulates superoxide release and is a prophylactic agent for CGD. It has been shown in vitro and in vivo to correct at least in part alterations of the oxidative metabolism, and to improve their microbicidal function.
How is granulomatous disease diagnosed?
Your doctor may order several tests to diagnose CGD , including: Neutrophil function tests. Your doctor may conduct a dihydrorhodamine 123 (DHR) test or other tests to see how well a type of white blood cell (neutrophil) in your blood is functioning. Doctors usually use this test to diagnose CGD .
What increases interferon-gamma?
High Interferon-Gamma LPS can be elevated by bacterial infections, a “leaky gut”, or other health conditions. Nitric oxide also increases interferon-gamma levels .
What is a gamma globulin blood test?
This test measures the levels of gamma globulins and other trace proteins found in blood serum. Gamma globulins (also called immunoglobulins) help the immune system fight off foreign substances and infections. Providers use this globulin test to diagnose conditions that affect the immune system, such as: Allergies.
What is the difference between gamma globulin and immunoglobulin?
Immunoglobulin (also called gamma globulin or immune globulin) is a substance made from human blood plasma. The plasma, processed from donated human blood, contains antibodies that protect the body against diseases.
What is gamma globulin blood test?
What is the difference between immunoglobulin and gamma globulin?
What is imukin used for?
Imukin contains interferon gamma-1b which is produced in the laboratory by recombinant technology. It modifies the body’s response to infection in the same way as naturally-occurring interferon gamma. Chronic Granulomatous Disease (CGD) is a rare disorder in which the body’s own natural defence against infection is not working properly.
Is imukin effective against X-linked disease?
However, there is some evidence to suggest that Imukin may be most effective in the young, in those with X-linked disease and in those with a history of more serious prior infection. In adult patients, a significant difference between Imukin and placebo has not been demonstrated.
What are the ingredients in imukin?
Imukin is an injection and each vial contains 2 million IU or 100 micrograms of interferon gamma-1b (recombinant) in 0.5 mL of solution. The solution also contains: mannitol sodium succinate hexahydrate
How does imukin work in chronic granulomatous disease (CGD)?
However, the mechanism of action of Imukin in chronic granulomatous disease (CGD) remains unknown. Clinical trials. In a placebo controlled clinical trial in patients with CGD, Imukin was shown to reduce the frequency of serious infections during the trial period of 12 months.