How does multiple myeloma affect the skull?

Multiple myeloma rarely involves the skull base. Cranial nerves II, III, IV, and VI are most often involved, but large lesions can affect other cranial nerves. Plasma cell neoplasms should be considered in the differential diagnosis of skull base tumors associated with cranial nerve palsy.

Can multiple myeloma cause skull lesions?

The classic radiographic appearance of multiple myeloma is that of multiple, small, well-circumscribed, lytic, punched-out, round lesions within the skull, spine, and pelvis. The pattern of lytic or punched-out radiolucent lesions on the skull have been described as resembling raindrops hitting a surface and splashing.

What is end stage multiple myeloma like?

As active multiple myeloma gets worse, you’ll likely feel sicker, with fatigue or bone pain. You may have anemia, bleeding problems, or a lot of infections. Other symptoms of advanced multiple myeloma include unusual fractures, shortness of breath, weakness, feeling very thirsty, and belly pain.

What does end of life look like with multiple myeloma?

Symptoms might include bone and/or nerve pain, loss of appetite, constipation, insomnia, nausea/vomiting, difficulty breathing, extreme fatigue, bleeding, anxiety, or sadness. Palliative care may be needed at any time during treatment, but is most often needed at the end of the disease course.

What does a lesion on the skull mean?

Skull lesions are usually discovered incidentally; they can be benign or malignant. • Metastases are the most frequent cause of skull lesions. • Metastatic lesions are most commonly due to breast cancer in adults and neuroblastoma in children.

What do multiple myeloma lesions look like?

What would cause lesions on the brain?

Brain lesions can be caused by injury, infection, exposure to certain chemicals, problems with the immune system, and more. Typically, their cause is unknown.

Can myeloma cause a brain tumor?

The present case indicates that multiple myeloma may manifest as an intracranial brain tumor (plasmacytoma).

What are the symptoms of a brain lesion?

What Are the Symptoms of a Brain Lesion?

• Headaches.
• Neck pain or stiffness.
• Nausea, vomiting, and lack of appetite.
• Vision changes or eye pain.
• Changes in mood, personality, behavior, mental ability, and concentration.
• Memory loss or confusion.
• Seizures.
• Fever.

Does myeloma affect the mind?

What is it? Myeloma and myeloma treatments can affect the brain’s ability to collect, retain and process information. ‘Chemo brain’ is a term used to describe the mind and memory issues cancer patients can experience. Your healthcare team may refer to these symptoms as cancer-related cognitive changes.

Can multiple myeloma cause neurological problems?

Patients with multiple myeloma (MM) often have neurologic complications. These include peripheral neuropathies, spinal radiculopathies, cranial nerve palsies, spinal cord compression, and a host of metabolic encephalopathies.

Can brain lesions affect behavior?

Impaired movement, if the lesion affects the part of the brain responsible for motor skills. Lack of concentration, the inability to make quick decisions, and agitation.

What is myeloma in the brain?

DISCUSSION. Multiple myeloma is a hematological malignancy characterized by a monoclonal proliferation of plasma cells. Patients may present with spinal cord or root compression as a result of vertebral collapse or extradural lesions [3].