Which can be used as a ion source in mass spectrometry?
Electron Ionization (EI) EI is one of the first and popular ionization methods for mass spectrometry. It is appropriate for organic molecules whose relatively molecule weight is below 600. In this technique, a current passes a wire filament can produce electrons for ionization.
What does the quadrupole mass spectrometer do?
The quadrupole mass analyzer acts as a mass filter, allowing one mass channel at a time to reach the detector as the mass range is scanned. Quadrupole mass spectrometers are intrinsically low-resolving-power instruments but are relatively cheap and robust.
How does quadrupole ion trap work?
Ions enter the quadrupole ion trap through the entrance endcap electrode. The ions are then trapped in the space between the electrodes by AC (oscillating, nonstatic) and DC (nonoscillating, static) electric fields. Various voltages are applied to the electrodes to trap and eject ions based on their m/z.
How does a mass spectrometer accelerate ions?
TOF MS employs a technique to measure the molecular weight of a substance. An electric field charges the ions, then they are released in a vacuum chamber. The ions retain a kinetic energy charge, which accelerates the ions toward a detector. Mass is calculated by the speed with which the atoms reach the detector.
What are ionization sources?
An EI source uses a filament set to about 70eV to create a stream of high-energy electrons that interact with the gas phase sample molecules. Ionization occurs when the collision removes an electron from the sample molecule, creating predominantly singly charged positive ions.
What is ion quadrupole interaction?
The electric quadrupole interaction represents the orientational energy of non-spherical nuclei in the electrostatic field produced by the electrons and ions in a solid. The latter is described by the tensor of the electric field gradient (EFG).
What is the notable advantage of the quadrupole mass spectrometer?
Quadrupole mass analyzers have several advantages such as no requirement for very high vacuum (> 10−7 Torr), and their relatively fast and simple operation for high-throughput analysis. Disadvantages include low transmittance, a low m/z cutoff, and low (generally unit) resolution.
What is linear trap quadrupole?
The linear ion trap uses a set of quadrupole rods to confine ions radially and a static electrical potential on-end electrodes to confine the ions axially. The linear form of the trap can be used as a selective mass filter, or as an actual trap by creating a potential well for the ions along the axis of the electrodes.
How does a triple quad work?
The triple quadrupole mass spectrometer (TQMS, or QqQ), is a tandem mass spectrometer made up of two quadrupole mass analyzers, with a (non-mass-resolving) radio frequency–only quadrupole between them, acting as a collision cell for collision-induced dissociation (CID) to fragment the selected precursors/parent ions.
Which part of the spectrometer is responsible for acceleration?
The positively charged ions are repelled from the ionisation chamber (which is positively charged), and pass through negatively charged slits which focus and accelerate this into a beam.
Which of the following ions would be deflected most in a mass spectrometer?
Lighter ions are deflected more than heavier ones. the charge on the ion. Ions with 2 (or more) positive charges are deflected more than ones with only 1 positive charge.