How is syphilis diagnosis diagnosed?

Syphilis can be diagnosed by testing samples of: Blood. Blood tests can confirm the presence of antibodies that the body produces to fight infection. The antibodies to the syphilis-causing bacteria remain in your body for years, so the test can be used to determine a current or past infection.

Which test is most diagnostic for syphilis?

Direct fluorescent antibody test for T pallidum It is the most specific test for the diagnosis of syphilis when lesions are present. This test uses fluorescein isothiocyanate-labelled antibody specific to pathogenic treponemes, and therefore is suitable for the examination of specimens from oral and rectal lesions.

What are the differential diagnosis of syphilis?

Syphilis must be differentiated from other common diseases that cause rash such as measles, rubella, Kawasaki disease , and mononucleosis. Syphilis also has overlapping symptoms with the other genital infections such as chancroid, condyloma acuminata, genital warts, herpes simplex, and herpes zoster.

What is the name of the confirmatory test for syphilis?

Treponemal tests, also called confirmatory tests (FTA, TP-PA, EIA), detect antibodies specific to syphilis. Treponemal antibodies will appear earlier after acute infection than non-treponemal antibodies. The antibodies detected in these tests usually remain detectable for life even after successful treatment.

What is a positive syphilis test?

It tests for syphilis antibodies. If it is positive, this could mean that you’ve had syphilis in the past, or that you have it now. It could also be a false positive. The sample will be sent for two more tests, including one to confirm the positive result.

What are the laboratory diagnosis of syphilis?

Currently, cases of possible syphilis are commonly investigated using the treponemal serological tests T. pallidum IgG chemiluminescence immunoassay (CLIA) and the T. pallidum particle agglutination (TPPA). The nontreponemal rapid plasma reagin (RPR) flocculation test is used to assess disease activity.

What diseases can be mistaken for syphilis?

It has been known itself to mimic other diseases and be difficult to diagnose. Common to this theme, syphilis has been misdiagnosed as a range of autoimmune diseases including Behcet’s disease,10 lichen planus,11 and inflammatory bowel disease.

How is secondary syphilis diagnosed?

To diagnose secondary syphilis, your doctor will do a physical examination and ask you questions about your medical history. If you have sores, your doctor might use a microscope to examine material taken from your sores. The syphilis bacteria will show up under the microscope.

Which test is better VDRL or TPHA?

VDRL test is less likely to identify syphilis except in primary stage of disease where TPHA may appear non- reactive. Moreover, it produces more false-positive results at all stages and more false-negative results in late disease.