What is the treatment for malignant hyperthermia?

Immediate treatment of malignant hyperthermia includes: Medication. A drug called dantrolene (Dantrium, Revonto, Ryanodex) is used to treat the reaction by stopping the release of calcium into muscles.

Which medications should be avoided during a MH crisis?

Triggering Agents According to the Malignant Hyperthermia Association of the United States (MHAUS), the following agents approved for use in the U.S. are known triggers of MH: inhaled general anesthetics, halothane, desflurane, enflurane, ether, isoflurane, sevoflurane, and succinylcholine.

How does dantrolene reverse hyperthermia?

Malignant Hyperthermia Dantrolene is the drug of choice for the treatment of MH crisis. Dantrolene works by blocking the release of calcium from the sarcoplasmic reticulum of skeletal muscle cells.

How do you administer Ryanodex?

Dosage in adults and pediatrics Administer RYANODEX® by intravenous push at a minimum dose of 1 mg/kg. If the physiologic and metabolic abnormalities of MH continue, administer intravenous pushes up to the maximum cumulative dosage of 10 mg/kg.

How is dantrolene administered?

Dantrium Intravenous should be administered by continuous rapid intravenous push beginning at a minimum dose of 1 mg/kg, and continuing until symptoms subside or the maximum cumulative dose of 10 mg/kg has been reached.

What is the first thing you do if your patient is having an MH crisis?

We recommend immediate administration of dantrolene (Grade 1A). The initial dose is 2.5 mg/kg intravenous (IV), to be given rapidly. The ETCO2 typically normalizes within minutes; subsequent bolus doses of 2.5 mg/kg IV every five minutes (up to 10 mg/kg) may be needed if signs of MH have not abated.

Why is mannitol added to dantrolene?

In contrast, pre-treatment with dantrolene alone did not prevent the cardiac complications associated with intra-cranial hypertension. In conclusion, 15% mannitol attenuated the cardiopulmonary complications associated with intra-cranial hypertension. Dantrolene without mannitol was without effect.

Which is an alternative anesthetic agent and will not trigger malignant hyperthermia?

Anesthetic agents, which may trigger MH in susceptible individuals, are the depolarizing muscle relaxant, succinyl choline and all the volatile anesthetic gasses. Nitrous oxide, intravenous induction agents, benzodiazepines, opioids, and the non-depolarizing relaxants do not trigger MH.

Is RYANODEX the same as dantrolene?

RYANODEX® is a formulation of dantrolene sodium that, through its technology, addresses deficiencies of other dantrolene sodium products.