Is melphalan hazardous?
Is melphalan hazardous?
Cancer Hazard * Melphalan is a CARCINOGEN in humans. It has been shown to cause leukemia in humans and lung cancer in animals.
Is melphalan soluble in water?
Melphalan salt is practically insoluble in acetone and chlorinated organic solvents. Slightly soluble in methanol and ethanol. Soluble in water, 0.1 N HCI and 0.1 N NaOH.
How do you dissolve melphalan?
A stock solution may be made by dissolving the melphalan in the solvent of choice. Melphalan is soluble in organic solvents such as methanol and DMSO which should be purged with an inert gas. The solubility of melphalan in these solvents is approximately 2 and 5 mg/ml, respectively.
How is melphalan administered?
Melphalan injection comes as a powder to be mixed with liquid to be slowly injected intravenously (into a vein) over 15 to 30 minutes by a doctor or nurse in a medical facility.
What is Melphalan made of?
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Which isomer of melphalan is more active?
Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer.
What class of drug is melphalan?
Melphalan belongs to the group of medicines called alkylating agents (cancer medicines). It works by interfering with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal cells may also be affected by melphalan, other unwanted effects will also occur.
What type of chemotherapy is melphalan?
Drug type: Melphalan is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.” (For more detail, see “How this drug works” section below).
How is melphalan metabolized?
Melphalan does not undergo metabolic activation and is inactivated in the plasma, primarily by non-enzymatic hydrolysis to monohydroxymelphalan and dihydroxymelphalan. Apart from these hydrolysis products, no other melphalan metabolites have been detected in humans (GlaxoSmithKline, 2007).
Is melphalan a prodrug?
Melphalan flufenamide is a melphalan prodrug used to treat relapsed or refractory multiple myeloma.
What is melphalan made from?
Melphalan belongs to the class of nitrogen mustard alkylating agents. It works by interfering with the creation of DNA and RNA. Melphalan was approved for medical use in the United States in 1964….Melphalan.
| Clinical data | |
|---|---|
| IUPAC name 4-[bis(2-Chloroethyl)amino]-L-phenylalanine | |
| CAS Number | 148-82-3 |
| PubChem CID | 460612 |
| IUPHAR/BPS | 7620 |