What is the action of flecainide?
Flecainide is used to prevent certain types of life-threatening irregular heartbeats. Flecainide is in a class of medications called antiarrhythmics. It works by slowing electrical signals in the heart to stabilize the heart rhythm.
Can flecainide cause right bundle branch block?
Abstract. In the setting of flecainide toxicity, supraventricular tachycardia can manifest as a bizarre right or left bundle branch block, sometimes with a northwest axis, and can easily be mistaken for ventricular tachycardia leading to inappropriate therapy.
What is the black box warning for flecainide?
A black box warning alerts doctors and patients to potentially dangerous effects. If you’ve had a heart attack within the past two years, flecainide may raise your risk of having another heart attack, which can be fatal. This drug should only be used if you have a life-threatening irregular heart rate.
What class of antiarrhythmic is flecainide?
Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials.
How does flecainide affect action potential?
Flecainide produced a concentration-dependent decrease in maximal rate of rise of phase 0 of the action potential (Vmax), action potential amplitude and overshoot potential with an in· crease in the effective refractory period in ventricular muscle.
Is flecainide a beta blocker?
We will tell you to take a dose of your anti-arrhythmic medication when you have an AF episode to help stop it. These will include either flecainide, a beta blocker or possibly a calcium channel blocker.
Why do I have to take metoprolol with flecainide?
Conclusion: Flecainide-metoprolol combination therapy improves effectiveness of rhythm control in persistent symptomatic AF and increases tolerability, with a concomitant reduction of side effects and a better compliance.
What drugs should not be taken with flecainide?
Do not take this medicine with any of the following medications: amoxapine. arsenic trioxide. certain antibiotics like clarithromycin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, sparfloxacin, or troleandomycin.
Does flecainide stop SVT?
Descriptions. Flecainide is used to prevent or treat irregular heartbeats (arrhythmias) such as paroxysmal supraventricular tachycardia (PSVT) and paroxysmal atrial fibrillation/flutter (PAF). Flecainide is also used to prevent life-threatening sustained ventricular tachycardia (sustained VT).
Does flecainide increase action potential duration?
The new antiarrhythmic drug flecainide (2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl) benzamide acetate) increases action potential duration at 30 and 90% repolarization, and functional refractory period in guinea pig papillary muscle up to 10 mumol/L, but shortens the action potential and decreases its …
Who makes flecainide?
Brand names. Flecainide is sold under the trade name Tambocor (manufactured by 3M pharmaceuticals).