How do you give a streptokinase infusion?

How do you give a streptokinase infusion?

Instill 250,000 IU Streptokinase in 2 mL of solution into each occluded limb of the cannula slowly. Clamp off cannula limb(s) for 2 hours. Observe the patient closely for possible adverse effects. After treatment, aspirate contents of infused cannula limb(s), flush with saline, reconnect cannula.

How do you give streptokinase to a pulmonary embolism?

Current guidelines on streptokinase in the treatment of massive pulmonary embolism state that it should be given as a loading dose of 250 000 IU over 20–30 min followed by an infusion of 100 000 IU/h intravenously for up to 24 h.

What is streptokinase used to treat?

Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. This medicine may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis) .

What are the side effects of streptokinase?

Common side effects of Streptase (streptokinase) include:

  • nausea,
  • headache,
  • dizziness,
  • low blood pressure,
  • mild fever,
  • bleeding from wounds or gums,
  • rash,
  • itching,

What are the negative effects of streptokinase?

The most common ADRs were chest pain, hypotension, coughing, and ecchymosis with the frequency of more than fifty percent. The hemorrhagic stroke as the most serious ADR of streptokinase was documented in three patients.

How much does streptokinase cost?

The Red Book average wholesale price of 1.5 million units of streptokinase was $320; the price of 100 mg of t-PA was $2,750. The average cost to the 16 GUSTO hospitals was $270 for 1.5 million units of streptokinase and $2,216 for 100 mg of t-PA.

What drugs are used in thrombolytic therapy?

The most commonly used clot-busting drugs — also known as thrombolytic agents — include:

  • Eminase (anistreplase)
  • Retavase (reteplase)
  • Streptase (streptokinase, kabikinase)
  • t-PA (class of drugs that includes Activase)
  • TNKase (tenecteplase)
  • Abbokinase, Kinlytic (rokinase)