What is the MOA of Namenda?

What is the MOA of Namenda?

Mechanism of Action Namenda, a low to moderate affinity NMDA (N-methyl-D-aspartate) receptor antagonist is thought to selectively block the effects associated with abnormal transmission of the neurotransmitter glutamate, while allowing for the physiological transmission associated with normal cell functioning.

Why is memantine used for Alzheimer’s?

Memantine is used to treat the symptoms of Alzheimer’s disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain.

Is memantine a neuroprotective?

Memantine is an excellent example of neuroprotective drug. It is a well-known uncompetitive voltage-dependent NMDA receptor antagonist, targeting principally NMDAR pathological hyperfunction26, and approved in 2003 by FDA as a treatment option for moderate to severe AD.

What is the difference between Aricept and Namenda?

Aricept and Namenda belong to different drug classes. Aricept is a cholinesterase inhibitor and Namenda is an orally active NMDA receptor antagonist.

What are the side effects of Namenda?

Common side effects of Namenda include:

  • tiredness,
  • body aches,
  • joint pain,
  • dizziness,
  • nausea,
  • vomiting,
  • diarrhea,
  • constipation,

What is the new drug for Alzheimer’s?

Aducanumab (Aduhelmâ„¢) has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration (FDA). This is the first FDA-approved therapy to address the underlying biology of Alzheimer’s disease.

What drug inhibits acetylcholinesterase?

Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine in the brain.