What does a positive parietal cell antibody test mean?

What does a positive parietal cell antibody test mean?

A decreased vitamin B12 level and/or increased methylmalonic acid and homocysteine levels as well as a positive test result for intrinsic factor antibodies and/or parietal cell antibodies means that it is likely that the person tested has pernicious anemia.

What causes high parietal cell antibodies?

Autoantibodies to antigens of gastric parietal cells (parietal cell antibodies) occur with high frequency in patients with pernicious anemia and atrophic gastritis.

What is the major target of anti-parietal cell antibodies?

Anti-Parietal Cell Antibodies (APCA) target the H+/K+ATPase (proton pump).

What does a negative intrinsic factor test mean?

When a person has a decreased vitamin B12 level and/or increased methylmalonic acid and homocysteine levels and has IF antibodies, then it is likely that the person has pernicious anemia. A negative test result does not necessarily mean that a person does not have pernicious anemia.

What is APCA test?

An antiparietal cell antibody test is a blood test that looks for antibodies against the parietal cells of the stomach. The parietal cells make and release a substance that the body needs to absorb vitamin B12. Alternative Names. APCA; Anti-gastric parietal cell antibody.

What causes autoimmune gastritis?

pylori, usually causes atrophic gastritis. Around half of people with H. pylori-related gastritis will develop atrophic gastritis. Otherwise, atrophic gastritis can be an inherited or genetic condition, which is called autoimmune atrophic gastritis.

Is a negative intrinsic factor good?

intrinsic factor normal range Less than 1.20 AU/mL is considered negative and more than 1.53 AU/mL is positive. These results are not taken into consideration while making a diagnosis without first doing other tests.

Is pernicious anemia an autoimmune disease?

Pernicious anaemia is an autoimmune condition that affects your stomach. An autoimmune condition means your immune system, the body’s natural defence system that protects against illness and infection, attacks your body’s healthy cells. Vitamin B12 is combined with a protein called intrinsic factor in your stomach.

What is the normal range for methylmalonic acid?

Normal values are 0.07 to 0.27 micromoles per liter. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

What are parietal cells?

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food, absorption of minerals, and control of harmful bacteria.

Is autoimmune gastritis curable?

People with autoimmune atrophic gastritis have a good prognosis with early detection and treatment. They may require B-12 injections to help prevent complications.

Can vitamin B12 deficiency cause gastritis?

Atrophic gastritis was more common in individuals with B12 deficiency, while superficial gastritis was the most common finding in controls. The incidence of intestinal metaplasia (in the antrum) was similar in the individuals with or without B12 deficiency.