Why is folic acid given in hereditary spherocytosis?

Why is folic acid given in hereditary spherocytosis?

Medication Summary. The goals of pharmacotherapy for hereditary spherocytosis are to reduce morbidity and prevent complications. Folic acid supplementation is indicated to prevent megaloblastic crisis.

What are the clinical features of hereditary spherocytosis?

Hereditary spherocytosis is a condition that affects red blood cells. People with this condition typically experience a shortage of red blood cells (anemia ), yellowing of the eyes and skin (jaundice), and an enlarged spleen (splenomegaly).

What are the causes of spherocytosis?


  • Warm autoimmune hemolytic anemia.
  • Cold autoimmune hemolytic anemia/paroxysmal cold hemoglobinuria.
  • Acute and delayed hemolytic transfusion reactions.
  • ABO hemolytic diseases of newborn/Rh hemolytic disease of newborn.
  • Hereditary spherocytosis.
  • Intravenous water infusion or drowning (fresh water)
  • Hypophosphatemia.

Can you donate blood if you have hereditary spherocytosis?

1. Must not donate if: Clinically significant haemolysis.

What kind of disorder is hereditary spherocytosis?

Hereditary spherocytosis is an inherited blood disorder. It happens because of a problem with the red blood cells (RBCs). Instead of being shaped like a disk, the cells are round like a sphere.

What is the confirmatory test for hereditary spherocytosis?

The combination of the eosin-5′-maleimide-binding test and acidified glycerol lysis test enabled all patients with hereditary spherocytosis to be identified. The eosin-5′-maleimide-binding test showed the greatest disease specificity.

How do you test for hereditary spherocytosis?

A blood draw will be done to get a complete blood count, an immature red blood cell (reticulocyte) count, and a look at the shape of red blood cells to look for spherocytes. It is also important to rule out autoimmune hemolytic anemia. This can be done with a direct antiglobulin test.