What complication is associated with acetaminophen overdose?
What complication is associated with acetaminophen overdose?
Acetaminophen poisoning is a common cause of liver damage (hepatotoxicity). Certain groups of people are more vulnerable to liver damage than others. Children and adolescents who already have liver disease or hepatitis A, B, or C are more likely to have severe symptoms after taking too much acetaminophen.
What is the most serious toxic effect of acute acetaminophen overdose?
Acetaminophen in overdose can seriously damage the liver. If the damage is severe, a liver transplant may be necessary in order to save a life. The antidote to acetaminophen overdose is N-acetylcysteine (NAC). It is most effective when given within 8 hours of ingesting acetaminophen.
What is the complication of acetaminophen?
Occasionally, the drug can cause serious side effects, including severe skin reactions and allergic reactions. Large doses of Tylenol can initially trigger stomach cramps and nausea before physical conditions quickly deteriorate, leading to liver injury, liver failure and death.
Which drugs cause drug eruption?
The most common drugs that may potentially cause drug eruptions include amoxicillin, trimethoprim sulfamethoxazole, ampicillin, penicillin, cephalosporins, quinidine and gentamicin sulfate.
What is the pathophysiology of acetaminophen toxicity?
Pathophysiology of Acetaminophen Poisoning or undernutrition could increase risk of toxicity because hepatic enzyme preconditioning may increase formation of NAPQI and because undernutrition (also common among alcoholics) reduces hepatic glutathione stores.
What causes drug eruption?
What causes drug eruptions? Immediate reactions occur within an hour of exposure to the drug and are mediated by IgE antibodies (urticaria, anaphylaxis). Delayed reactions occur between 6 hours and several weeks of first exposure to the drug. They may be mediated by IgG antibody, immune complex, or cytotoxic T cells.
Can Tylenol cause bruising?
Official Answer. Bruising is not a common side effect of Tylenol (acetaminophen).
How does acetaminophen toxicity occur?
Acetaminophen toxicity or overdose can occur purposefully (when a person knowingly takes more than the recommended maximum daily dose) or accidentally (when a person is unaware they are taking multiple products containing acetaminophen and exceeds the recommended maximum daily dose).