What is colon specific drug delivery system?
What is colon specific drug delivery system?
The colon specific drug delivery System (CDDS) is beneficial not only for the oral delivery of proteins and peptide drugs (degraded by digestive enzymes of stomach and small intestine) but also for the delivery of low molecular weight compounds used to treat diseases associated with the colon or large intestine such as …
Which of the following is colon specific polymer?
5)[1,19]. Chitosan is a nontoxic, biodegradable, biocompatible and bioactive polymer. Chitosan is used as excipient and drug carrier in drug delivery systems. Chitosan is used for the colon targeted drug delivery because it has a tendency to dissolve in acidic pH of stomach but get swollen in the intestinal pH.
What should be considered on design of a colon specific prodrug?
Take home message: On design of a colon-specific prodrug, one should take into consideration not only delivery of a drug to the target site, but also the therapeutic effectiveness there.
Which system is approach for colon targeting?
Methods: The various strategies for targeting orally administered drugs to the colon include covalent linkage of a drug with a carrier, coating with pH-sensitive polymers, formulation of timed released systems, exploitation of carriers that are degraded specifically by colonic bacteria, bioadhesive systems and osmotic …
Why is the colon targeted a drug delivery system?
Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer.
What is the function of colon?
The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon, is stored in the rectum, and leaves the body through the anus.
What does the colon do?
The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon, is stored in the rectum, and leaves the body through the anus. The colon is part of the digestive system.